How Cerbrexum™ Works...
Growing older can be hard on our brains. As we age, our bodies tend to produce more cortisol. And rising levels of this “fight-or-flight” stress hormone negatively impact brain health. Especially the cerebral cortex and hippocampus – areas directly linked to memory, focus and concentration.
At the same time, our bodies also produce less acetylcholine, or ACh. This critical neurotransmitter carries signals from our brains throughout our bodies. Your brain uses ACh to control your muscles and autonomic nervous system, including your heart, breathing and digestion.
Acetylcholine also carries signals between regions of the brain. And it’s essential for communication between neurons in the hippocampus – your brain’s center of learning and memory. It even helps boost neuron activity, which in turn enhances both memory encoding and the performance of other neurotransmitters.
Unfortunately, our ACh levels decline as we grow older. It can start as early as age 45, but age isn’t the only factor. Increased stress can also trigger a breakdown of ACh. And as we lose ACh, our brains become less and less efficient (Gibson and Peterson 1981).
However, cognitive decline is NOT inevitable.
Study after study shows that certain nutrients can help our brains work better. The hormone DHEA helps block cortisol receptors. And increasing our DHEA levels can help control high cortisol levels as well as the damage they inflict.
Similarly, the more acetylcholine we have, the more efficient our brains are. And the better we are at storing and recalling data in our memories. So reducing stress and increasing ACh can boost memory, focus and cognitive function (Khalsa 2015).
That's how Cerbrexum™ can help. Each daily dose is bursting with FOUR powerful brain-boosting nutrients that can help reduce stress, raise DHEA and ACH levels, and more.
Brain Booster #1: Ashwagandha
Ashwagandha is renowned for its ability to balance, revitalize, rejuvenate, and energize. Ayurvedic practitioners have used it for thousands of years to reverse the cognitive effects of stress and aging (Singh et al. 2011).
And modern science shows Ashwagandha not only works, but works extremely well (Bruce 2014).
For instance, one randomized, double-blind, placebo-controlled study looked at the potential benefits of Sensoril®, a multi-patented Ashwagandha extract. And the results were astounding. It found a 250 mg/day dose reduced forgetfulness by 57.1%, and improved focus by 75.8%! (Auddy et al. 2008)
How did Sensoril® achieve these impressive results?
In a nutshell, Ashwagandha is an adaptogen. It helps the body resist negative stresses and return to a state of balance, or homeostasis. And it does this partly by using withanolide bioactives to lower cortisol levels and increase serum DHEA.
Sensoril® is standardized to contain at least 8% withanolides. As a result, it boosted serum DHEA levels to 32.2% and cut cortisol levels by 24.2% in one trial. Which helped reduce stress and prevent critical ACh levels from dropping (Auddy et al. 2008).
We were so impressed with Sensoril®, we formulated Cerbrexum™ to include the same dosage used in the clinical trial. You get a full 250 mg in each daily dose!
Brain Booster #2: Huperzine A
In addition to Ashwagandha, Cerbrexum™ also gives you 25 mcg of Huperzine A. This powerful alkaloid comes from Huperzineserrata, better known as “Toothed Clubmoss.” And it too is a powerful cognitive enhancer.
First, Huperzine A targets and blocks enzymes that break down acetylcholine (ACh). This raises ACh levels, which improves cognitive function (Wang, Yan and Tang 2006).
And that's not all. It also helps safeguard neurons against glutamate, beta-amyloid pigmentation and H2O2-induced toxicity (Xing et al. 2014).
Plus, evidence suggests Huperzine A may promote nerve cell growth. A study published in Brain Research found it caused in vitro neural stem cells to grow more than twice as fast as the control group. And in vivo tests not only confirmed the neurogenesis. They produced a 25% increase of cell growth in just 4 weeks! (Ma et al. 2013)
Brain Booster #3: Lion’s Mane
The third brain-boosting nutrient you get with Cerbrexum™ is Lion’s Mane. The Yamabushitake mushroom, or Lion’s Mane, is another of nature’s powerful protectors against cognitive decline (Mori et al. 2009).
In clinical studies, Lion’s Mane caused a five-fold increase in brain nerve growth factor (NGF) expression. As well as protected neurons and enhanced their production in the myelin sheath. But these are just the tip of the iceberg (Kolotushkina et al. 2003).
Lion’s Mane has also been linked a whole host of additional benefits. Including cardiovascular health... weight loss... even nerve regeneration. And Cerbrexum™ gives you a whopping 500 mg of Lion’s Mane in each daily dose!xiii
Brain Booster #4: Vitamin D
Most people know our bodies produce Vitamin D as a direct result of exposure to sunlight. Or that you can get it from eggs, fish, and milk (with vitamin D added). But even so, many – if not most – of us don’t get enough. Especially if you are older or live in an area where there isn’t plenty of sunshine.
And that’s a serious concern. Clinical studies link low vitamin D levels to memory loss and reduced cognitive function – especially in older adults (Boggs, 2015).
Scientists are still working to determine the exact connection. But the importance of making sure you get enough is crystal clear. Because the lower our vitamin D levels, the longer it takes to process information. And the worse we are at performing at memory-related tasks (Welland 2009).
So how much vitamin D do you need?
The recommended dietary allowance (RDA) of vitamin D is 600 IU/day. However, you should consider that the bare minimum. Most experts recommend a much higher dose – between 1,000 and 2,000 IU/day.xvi
That's why we formulated Cerbrexum™ to include a full 2,000 IU of vitamin D in each daily dose. So you'll never have to worry about getting enough!
Footnotes: Scientific Studies on Cerbrexum Ingredients
Auddy B, Hazra J, Mitra A, B. Abedon and S. Ghosal. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans; a double-blind, randomized, placebo-controlled study. J Am Nutra Assoc 2008. 11(1):51-57
Boggs, Will, M.D. “Low vitamin D levels linked to faster memory loss in older adults”; Reuters.com; 4 Sep 2015
Bruce A., Nutraceutical Supplementation Enhances Mental Cognition (2009); Pingali U, Pilli R, Fatima N. “Effectof standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.” Pharmacognosy Res. 2014 Jan;6(1):12-8. doi: 10.4103/0974-8490.122912.PMID: 24497737
Gibson GE, Peterson C. Aging decreases oxidative metabolism and the release and synthesis of acetylcholine. J Neurochem. 1981 Oct;37(4):978-84
Khalsa DS. Stress, Meditation, and Alzheimer's Disease Prevention: Where The Evidence Stands. J Alzheimers Dis. 2015;48(1):1–12. doi:10.3233/JAD-142766
Kolotushkina, EV, MG Moldavan, KY Voronin, and GG Skibo. The influend of Hericium erinaceus extract on melination process in vitro. Fiziol Zh. 2003:49(1):38-43.
Lopresti AL, Drummond PD, Smith SJ. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. Am J Mens Health. 2019;13(2):1557988319835985. doi:10.1177/1557988319835985
Ma T, Gong K, et al. “Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.” Brain Research. 2013 Apr 19;1506:35-43. doi: 10.1016/j.brainres.2013.02.026. Epub 2013 Feb 27. PMID: 23454433
Mori, K, S inatomi, K Ouichi, Y Azumi, and T Tuchida. Improving efects of the mushroom Yambushitake (Hiericium erinaceus) on a mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 mar; 23(3):367-72.
Nagano M, et al. “Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake” Biomed Research 2010 Aug; 31(4):231-7
National Institute of Health (NIH). Vitamin D Fact Sheet for Professionals. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#refls.
Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. BMC Complement Altern Med. 2013;13:261. Published 2013 Oct 11. doi:10.1186/1472-6882-13-261
Ratto D, Corana F, Mannucci B, et al. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019;11(4):715. Published 2019 Mar 27. doi:10.3390/nu11040715
Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208–213. doi:10.4314/ajtcam.v8i5S.9
Wang R, Yan H, Tang XC (2006) Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin 27:1–26
Welland, Diane. “Does Vitamin D Improve Brain Function?” Scientific American; 1 November 2009
Xing, Shu-huai et al. “Huperzine A in the Treatment of Alzheimer’s Disease and Vascular Dementia: A Meta-Analysis” Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 363985
Zhang Y, Fang F, Tang J, et al. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ. 2019;366:l4673. Published 2019 Aug 12. doi:10.1136/bmj.l4673
DISCLAIMER: Talk to your doctor or health care provider to determine if Cerbrexum™ is right for you and is safe to take with your medications. Do not start or stop any prescribed medication or treatment without first consulting your doctor or health care provider.